crippling blow

Translations
сокрушительный удар
The company suffered a crippling blow when its main product was recalled.
Компания понесла сокрушительный удар, когда ее основной продукт был отозван.
Definitions
A crippling blow refers to a significant and damaging impact, either physically or metaphorically, that severely hinders someone's ability to function or recover. It can describe a literal injury or a devastating setback in a situation.